Network pharmacology-based study in polymetformin’s new function of blocking ages/rage pathway curing diabetic complications

Network pharmacology-based study in polymetformin’s new function of blocking ages/rage pathway curing diabetic complications

Abstract Advanced Glycation End Products (AGEs) are the molecular mediators that contribute to the progression of diabetic complications. However, there is a paucity of research on effective AGEs inhibitors and strategies for blocking the AGEs-RAGE pathway. To solve the problem, we synthesized polym...

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Bibliographic Details
Main Authors: Linghong Kong, Hui Wang, Weiwei Jiang, Yun Chen, Zhuoling Du, Qiong Zhang, Jianyue Dong, Changchun Zeng, Hanping Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Advanced glycation End-products
Polymetformin
Endothelial dysfunction
AGEs-RAGE pathway.
Online Access:https://doi.org/10.1038/s41598-025-00956-w
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https://doi.org/10.1038/s41598-025-00956-w

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