Gasdermin D mutation protects against renal ischemia reperfusion injury

Gasdermin D mutation protects against renal ischemia reperfusion injury

Abstract Pyroptosis, the most inflammatory form of cell death, is dependent on membrane pore formation governed by the assembly of cleaved Gasdermin D (GSDMD). We hypothesized that regulated necrosis pathways are crucial in the pathophysiology of acute kidney injury (AKI). Mice with an isoleucine‐to...

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Main Authors: Jennifer S. Y. Li, Aadhar Moudgil, Daniel N. Meijles, Karli Shaw, Sohel M. Julovi, Katie Trinh, Stephen I. Alexander, Natasha M. Rogers
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Physiological Reports
Subjects:
acute kidney injury
gasdermin D
renal tubular epithelial cells
Online Access:https://doi.org/10.14814/phy2.70254
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https://doi.org/10.14814/phy2.70254

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