Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk

Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk

Background: In this study, we investigated the genetic connections between attention-deficit/hyperactivity disorder (ADHD), migraine (MGN), and multisite chronic pain (MCP). The goal was to identify specific shared biological mechanisms that contribute to the overlap between ADHD and these pain-rela...

Full description

Saved in:

Bibliographic Details
Main Authors:	Nicolas P. Ciochetti, Victor F. de Oliveira, Iago Junger-Santos, Cibele E. Bandeira, Maria E. Tavares, Eduardo S. Vitola, Luis A. Rohde, Gustavo Melo de Andrade, Bruna S. da Silva, Eugenio H. Grevet, Claiton H. Dotto Bau, Diego L. Rovaris
Format:	Article
Language:	English
Published:	Elsevier 2025-07-01
Series:	Biological Psychiatry Global Open Science
Subjects:	Attention-deficit/hyperactivity disorder Genome-wide association study Migraine Pain Pleiotropy Polygenic risk score
Online Access:	http://www.sciencedirect.com/science/article/pii/S2667174325000710
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Polygenic prediction of human longevity on the supposition of pervasive pleiotropy
by: M. Reza Jabalameli, et al.
Published: (2024-08-01)

The genetic overlap and causal relationship between attention deficit hyperactivity disorder and obstructive sleep apnea: a large-scale genomewide cross-trait analysis
by: Yao Tong, et al.
Published: (2025-05-01)

Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation
by: Wei-Yun Lai, et al.
Published: (2025-04-01)

Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness
by: Christopher R Bauer, et al.
Published: (2015-01-01)

Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans
by: Yifan Xiang, et al.
Published: (2025-08-01)

A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics
by: Richard Head, et al.
Published: (2025-08-01)

A phenomenological-temporal perspective on inattention and hyperactivity
by: Daniel Victor Barbosa Magalhaes, et al.
Published: (2025-05-01)

Concordância entre observadores para o diagnóstico em adultos do trantorno de déficit de atenção/hiperatividade e transtorno de oposição desafiante utilizando o K-SADS-E Interrater reliability for diagnosis in adults of attention deficit hyperactivity disorder and oppositional defiant disorder using K-SADS-E
by: Eugenio Horácio Grevet, et al.
Published: (2005-06-01)

Inheritance of Indehiscent Capsule Character, Heritability and Genetic Advance Analyses in the Segregation Generations of Dehiscent x Indehiscent Capsules in Sesame
by: Engin Yol, et al.
Published: (2019-03-01)

Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices
by: BaHammam AS, et al.
Published: (2024-11-01)

Exploring the Pleiotropy of PCSK9: A Wide Range of Influences from Lipid Regulation to Extrahepatic Function
by: Wang H, et al.
Published: (2025-03-01)

THE SYSTEM OF COMPLEX REHABILITATION OF CHILDREN WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER: NOVEL APPROACH TOWARDS OBSERVATION AND TREATMENT
by: O. R. Nogovitsina, et al.
Published: (2012-01-01)

Prevalence of Attention-Deficit Hyperactivity Disorder in India: A Systematic Review and Meta-Analysis
by: Johny Kutty Joseph, et al.
Published: (2019-07-01)

Clonidine in Hyperactive, Mentally Retarded Children
by: J Gordon Millichap
Published: (2001-09-01)

A Trade‐Off Between Antimicrobial Peptide Resistance and Sensitivity to Host Immune Effectors in Staphylococcus aureus In Vivo
by: Baydaa El Shazely, et al.
Published: (2025-02-01)

Attention-deficit/hyperactivity disorder
by: A. M.E. du Plessis
Published: (2015-05-01)

Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes
by: Jordan Greaves, et al.
Published: (2025-01-01)

The effect of instructional design models and methods on motivation and achievement of learners with attention deficit hyperactivity disorder (ADHD)
by: H Zare, et al.
Published: (2016-04-01)

Infant Crying and Risk of Hyperactivity and Learning Disorders
by: J Gordon Millichap
Published: (2002-06-01)

Clinical Aspects of a Rare Disease: Bardet Biedl Syndrome
by: Ina Ofelia FOCSA, et al.
Published: (2022-03-01)

The potential of inversions to accumulate balanced sexual antagonism is supported by simulations and Drosophila experiments
by: Christopher S McAllester, et al.
Published: (2025-04-01)

Transcriptomic Dysregulation in Animal Models of Attention‐Deficit Hyperactivity Disorder and Nicotine Dependence Suggests Shared Neural Mechanisms
by: Sarah Van Horn, et al.
Published: (2025-03-01)

Polygenic risk score prediction accuracy convergence
by: Léo Henches, et al.
Published: (2025-07-01)

BENEFITS OF NON-CONVENTIONAL MEDICINE IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER
by: Y. Georgiev
Published: (2025-06-01)

Commentary: Relationships between screen time and childhood attention deficit hyperactivity disorder: a Mendelian randomization study
by: Nagahide Takahashi, et al.
Published: (2024-12-01)

White matter alterations related to attention-deficit hyperactivity disorder and COMT val158met polymorphism: children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus)
by: Kabukçu Başay B, et al.
Published: (2016-04-01)

Lipophilic bisphosphonates reduced cyst burden and ameliorated hyperactivity of mice chronically infected with Toxoplasma gondii
by: Melissa A. Sleda, et al.
Published: (2024-11-01)

CLINICAL AND URODYNAMIC PARALLELS IN IDIOPATHIC HYPERACTIVITY OF THE BLADDER: THE RESULTS OF 341 OBSERVATIONS
by: S. H. Al-Shukri, et al.
Published: (2017-07-01)

ATTENTION DEFICIT HYPERACTIVITY DISORDER. A CLINICAL LECTURE
by: A. S. Kotov, et al.
Published: (2015-06-01)

Attention deficit hyperactivity disorder: new in understanding and treatment approaches
by: E. A. Morozova, et al.
Published: (2019-05-01)

Paroxysmal Sympathetic Hyperactivity Syndrome (Review)
by: L. M. Tsentsiper, et al.
Published: (2022-08-01)

Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis
by: Katerina Placek, et al.
Published: (2020-12-01)

ATTENTION DEFICIT HYPERACTIVITY DISORDER: COMORBIDITIES, EMPHASIS ON CONCURRENCE WITH EPILEPSY
by: O. A. Pylaeva, et al.
Published: (2015-06-01)

Bidirectional two-sample Mendelian randomization analysis unveils causal association between inflammatory cytokines and the risk of diabetic nephropathy
by: Siyuan Song, et al.
Published: (2024-10-01)

Validation of the Expression and Emotion Scale for Children with attention deficit hyperactivity disorder into Brazilian Portuguese
by: Margarete Andreozzi Vaz Pereira Simon, et al.

Ketamine for rapid control of hyperactive delirium with severe agitation. A retrospective comparison study
by: Beatrice Borreani, et al.
Published: (2025-03-01)

Longitudinal patterns of attention-deficit/hyperactivity disorder children in Shanghai, China
by: XiaoYan Qiu, et al.
Published: (2025-06-01)

The study of mother’s knowledge regarding their children, s Attention Deficit ‎Hyperactivity Disorder ‎
by: fatemeh atar, et al.
Published: (2006-10-01)

Spectral Analysis of Light-Adapted Electroretinograms in Neurodevelopmental Disorders: Classification with Machine Learning
by: Paul A. Constable, et al.
Published: (2024-12-01)

Prevalence of attention-deficit hyperactivity disorders in students: comparison between DSM-IV and neuropsychological criteria
by: ANA GUARDIOLA, et al.
Published: (2000-06-01)