Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes

Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes

There is a large body of evidence implicating mitochondrial reactive oxygen species (ROS) overproduction and oxidative stress in the development of diabetic kidney disease and the deficiency of mitochondrial antioxidant systems in the kidney, such as manganese superoxide dismutase (MnSOD/SOD2) have...

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Bibliographic Details
Main Authors: Inez A. Trambas, Lilliana Bowen, Vicki Thallas-Bonke, Matthew Snelson, Karly C. Sourris, Adrienne Laskowski, Michel Tauc, Isabelle Rubera, Guoping Zheng, David C.H. Harris, Phillip Kantharidis, Takahiko Shimizu, Mark E. Cooper, Sih Min Tan, Melinda T. Coughlan
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Redox Biology
Subjects:
Diabetes
MnSOD
SOD2
Diabetic kidney disease
Oxidative stress
Proximal tubules
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001144
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