Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy.

Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy.

The aim of this study was to investigate the function of the Hippo pathway member Yes-associated protein (Yap, gene name Yap1) in skeletal muscle fibres in vivo. Specifically we bred an inducible, skeletal muscle fibre-specific knock-in mouse model (MCK-tTA-hYAP1 S127A) to test whether the over expr...

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Main Authors: Robert N Judson, Stuart R Gray, Claire Walker, Andrew M Carroll, Cecile Itzstein, Arimantas Lionikas, Peter S Zammit, Cosimo De Bari, Henning Wackerhage
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059622&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059622&type=printable

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