Genomic Comparisons Revealed the Key Genotypes of <i>Streptomyces</i> sp. CB03234-GS26 to Optimize Its Growth and Relevant Production of Tiancimycins

Genomic Comparisons Revealed the Key Genotypes of <i>Streptomyces</i> sp. CB03234-GS26 to Optimize Its Growth and Relevant Production of Tiancimycins

Strain robustness and titer improvement are major challenges faced in the industrial development of natural products from <i>Streptomyces</i>. Tiancimycins (TNMs) produced by <i>Streptomyces</i> sp. CB03234 are promising anticancer payloads for antibody-drug conjugates, but f...

Full description

Saved in:

Bibliographic Details
Main Authors:	Huiming Liu, Jing Lin, Yong Huang, Yanwen Duan, Xiangcheng Zhu
Format:	Article
Language:	English
Published:	MDPI AG 2024-11-01
Series:	Bioengineering
Subjects:	<i>Streptomyces</i> tiancimycins genome resequencing genotypes bioinformatics analysis alkaline tolerance
Online Access:	https://www.mdpi.com/2306-5354/11/11/1128
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The exploration of high production of tiancimycins in Streptomyces sp. CB03234-S revealed potential influences of universal stress proteins on secondary metabolisms of streptomycetes
by: Huiming Liu, et al.
Published: (2024-12-01)

Antibiotic Potential of Marine Actinomycetes of the Genera <i>Streptomyces</i> and <i>Nocardiopsis</i>
by: O. N. Sineva, et al.
Published: (2023-07-01)

Harnessing <i>Streptomyces</i> for the Management of Clubroot Disease of Chinese Cabbage (<i>Brassica rapa</i> subsp. <i>Pekinensis</i>)
by: Shan Chen, et al.
Published: (2025-07-01)

Genome Mining of Terpene Synthases from Fourteen <i>Streptomyces</i> Strains
by: Yuanyuan Li, et al.
Published: (2025-06-01)

<i>Streptomyces</i>-Based Bioformulation to Control Wilt of <i>Morchella sextelata</i> Caused by <i>Pestalotiopsis trachicarpicola</i>
by: Binghan Li, et al.
Published: (2025-06-01)

An Overview of Lsr2 Repressor Effect in <i>Streptomyces</i> spp. Secondary Metabolism
by: Lorena Cuervo, et al.
Published: (2024-11-01)

The α-Glucosidase Inhibition Activities of Phaeochromycins D and E Isolated from Marine <i>Streptomyces</i> sp. FJ0218
by: Pingfa Lin, et al.
Published: (2025-04-01)

Isolation of a Novel <i>Streptomyces</i> sp. TH05 with Potent Cyanocidal Effects on <i>Microcystis aeruginosa</i>
by: Xuhan Wang, et al.
Published: (2025-07-01)

<i>Streptomyces vinaceus</i> Mediating the Mechanism of Chinese Orchid Stomatal Closure to Enhance Resistance to Anthracnose
by: Jinai Yao, et al.
Published: (2025-05-01)

Mechanisms of Biodeterioration of Structural Materials by <i>Streptomyces</i> spp.: A Review
by: Nataliia Tkachuk, et al.
Published: (2024-08-01)

Biocontrol of <i>Cassida vittata</i> Vill. (Coleoptera: Chrysomelidae) in Sugar Beet Crops Using <i>Streptomyces</i> sp. Strains
by: Mohamed El Aalaoui, et al.
Published: (2025-02-01)

Soil Inoculated with <i>Streptomyces rochei</i> D74 Invokes the Defense Mechanism of <i>Helianthus annuus</i> Against <i>Orobanche cumana</i>
by: Jiao Xi, et al.
Published: (2025-07-01)

Growth Performance of French Guinea Fowl Broilers Fed the Probiotics <i>Lactobacillus reuteri</i> and <i>Streptomyces coelicolor</i>
by: Sarayu Bhogoju, et al.
Published: (2025-03-01)

Inhibitory Activity of Compounds Obtained from <i>Streptomyces</i> Against <i>Trypanosoma cruzi</i>
by: Jorge Andrés Delgado-Garduño, et al.
Published: (2025-06-01)

Comparative Genomics and Biosynthetic Cluster Analysis of Antifungal Secondary Metabolites of Three Strains of <i>Streptomyces albidoflavus</i> Isolated from Rhizospheric Soils
by: Adilene Gonzalez-Silva, et al.
Published: (2024-12-01)

Heterologous Expression of Type II PKS Gene Cluster Leads to Diversified Angucyclines in <i>Streptomyces albus</i> J1074
by: Xiaoting Zhang, et al.
Published: (2024-10-01)

Investigating novel Streptomyces bacteriophage endolysins as potential antimicrobial agents
by: Jindanuch Maneekul, et al.
Published: (2025-01-01)

Genomic and Phenotypic Characterization of <i>Streptomyces sirii</i> sp. nov., Amicetin-Producing Actinobacteria Isolated from Bamboo Rhizospheric Soil
by: Yuliya V. Zakalyukina, et al.
Published: (2024-12-01)

Biological Control of <i>Streptomyces</i> sp. PR69 Against <i>Phytophthora capsici</i> and Its Growth-Promoting Effects on Plants
by: Perla Karina López-Reyes, et al.
Published: (2024-12-01)

2-Amino-3-Chlorobenzoic Acid from <i>Streptomyces coelicolor</i>: A Cancer Antagonist Targeting PI3K/AKT Markers via miRNA Modulation
by: Ashraf Khalifa, et al.
Published: (2025-04-01)

Impact of the alkaline volatile trimethylamine on the physiology of Streptomyces venezuelae: an integrated transcriptomic and metabolomics study
by: Yanping Zhu, et al.
Published: (2025-07-01)

Improved Natamycin Production in <i>Streptomyces gilvosporeus</i> Through Mutagenesis and Enhanced Nitrogen Metabolism
by: Liang Wang, et al.
Published: (2025-02-01)

Characterization and Bioactive Metabolite Profiling of <i>Streptomyces</i> sp. Y009: A Mangrove-Derived <i>Actinomycetia</i> with Anticancer and Antioxidant Potential
by: Bo Yu, et al.
Published: (2024-11-01)

<i>Streptomyces flavusporus</i> sp. nov., a Novel Actinomycete Isolated from Naidong, Xizang (Tibet), China
by: Dan Tang, et al.
Published: (2025-04-01)

A VioA Variant Activates Antibiotic Streptogramins in the Heterologous Host <i>Streptomyces</i> sp. OUC20-O
by: Jie Shan, et al.
Published: (2025-05-01)

ScnR1-Mediated Competitive DNA Binding and Feedback Inhibition Regulate Guvermectin Biosynthesis in <i>Streptomyces caniferus</i>
by: Haoran Shi, et al.
Published: (2025-07-01)

Current Approaches for Genetic Manipulation of <i>Streptomyces</i> spp.—Key Bacteria for Biotechnology and Environment
by: Sergii Krysenko
Published: (2025-01-01)

Three New Depsipeptides, Homiamides A–C, Isolated from <i>Streptomyces</i> sp., ROA-065
by: Jeong-Hyeon Kim, et al.
Published: (2024-11-01)

Bioactive Secondary Metabolites from an Arctic Marine-Derived Strain, <i>Streptomyces</i> sp. MNP-1, Using the OSMAC Strategy
by: Mengna Wu, et al.
Published: (2025-04-01)

Genomic Insights and Antimicrobial Potential of Newly <i>Streptomyces cavourensis</i> Isolated from a Ramsar Wetland Ecosystem
by: Mabrouka Benhadj, et al.
Published: (2025-03-01)

Phenotypic Characterization and Whole-Genome Analysis Revealing the Promising Metabolic Potential of a Newly Isolated <i>Streptomyces</i> sp. CH6
by: Chung Thanh Nguyen, et al.
Published: (2025-06-01)

Synergistic Role of <i>Streptomyces</i> Composite Inoculants in Mitigating Wheat Drought Stress Under Field Conditions
by: Hao Shan, et al.
Published: (2025-01-01)

<i>GsEXPA8</i> Enhances Soybean Tolerance of NaHCO<sub>3</sub> Stress by Regulating Root Morphology
by: Mengyu Liu, et al.
Published: (2024-12-01)

Genomic and Transcriptomic Analysis of Mutant <i>Bacillus subtilis</i> with Enhanced Nattokinase Production via ARTP Mutagenesis
by: Liuyu Guo, et al.
Published: (2025-03-01)

Transcription Factor LjWRKY50 Affects Jasmonate-Regulated Floral Bud Duration in <i>Lonicera japonica</i>
by: Yanfei Li, et al.
Published: (2025-07-01)

A Novel Pyrazinone Derivative with Anti-MRSA Activity, Produced by <i>Streptomyces anulatus</i> Isolated from the Rhizosphere of <i>Malus trilobata</i> in Lebanon
by: Dany Abi Chahine, et al.
Published: (2025-04-01)

Copper and Zinc Sulfates Suppress <i>Streptomyces</i> spp. and Enhance Potato Resistance via Thaxtomin A Inhibition and Defense Gene Regulation
by: Nianzhou Chen, et al.
Published: (2025-05-01)

Population Genetic Characteristics of the Cultivated <i>Coffea arabica</i> with Whole-Genome Resequencing
by: Qin Zhang, et al.
Published: (2024-10-01)

Plant Growth-Promoting Effect and Complete Genomic Sequence Analysis of the Beneficial Rhizosphere <i>Streptomyces</i> sp. GD-4 Isolated from <i>Leymus secalinus</i>
by: Wanru Xu, et al.
Published: (2025-01-01)

THE PROPERTIES OF THE CONIDIA OF STRAINS OF THE ACTINOMYCETE <i>STREPTOMYCES LUCENSIS</i> AND <i>STREPTOMYCES VIOLACEUS</i> DURING STORAGE AT LOW TEMPERATURES
by: Natalya Yu. Sharova, et al.
Published: (2018-10-01)