Genomic Comparisons Revealed the Key Genotypes of <i>Streptomyces</i> sp. CB03234-GS26 to Optimize Its Growth and Relevant Production of Tiancimycins

Genomic Comparisons Revealed the Key Genotypes of <i>Streptomyces</i> sp. CB03234-GS26 to Optimize Its Growth and Relevant Production of Tiancimycins

Strain robustness and titer improvement are major challenges faced in the industrial development of natural products from <i>Streptomyces</i>. Tiancimycins (TNMs) produced by <i>Streptomyces</i> sp. CB03234 are promising anticancer payloads for antibody-drug conjugates, but f...

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Bibliographic Details
Main Authors: Huiming Liu, Jing Lin, Yong Huang, Yanwen Duan, Xiangcheng Zhu
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Bioengineering
Subjects:
<i>Streptomyces</i>
tiancimycins
genome resequencing
genotypes
bioinformatics analysis
alkaline tolerance
Online Access:https://www.mdpi.com/2306-5354/11/11/1128
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