Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity

Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity

Abstract BRAF and MEK inhibitors (BRAF/MEKi) have radically changed the treatment landscape of advanced BRAF mutation-positive tumours. However, limited efficacy and emergence of drug resistance are major barriers for successful treatments. Here, by using relevant preclinical models, we find that Co...

Full description

Saved in:
Bibliographic Details
Main Authors: Adrián Varela-Vázquez, Amanda Guitián-Caamaño, Paula Carpintero-Fernández, Alexander Carneiro-Figueira, Vanesa Álvarez, Marta Varela-Eirín, Teresa Calleja-Chuclá, Susana B. Bravo-López, Anxo Vidal, Juan Sendón-Lago, Marina Rodriguez-Candela Mateos, José R. Caeiro, Victoria Sanz-Moreno, Trond Aasen, Miguel G. Blanco, Guadalupe Sabio, María Quindós, Carmen Rivas, David Santamaría, Carlos Fernandez-Lozano, Eduardo Fonseca, Pablo Huertas, Berta Sánchez-Laorden, Constance Alabert, María D. Mayán
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60971-3
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-025-60971-3

Similar Items