TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD

TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD

Abstract Abnormality in transactivating response region DNA binding protein 43 (TDP43) is well-recognized as the pathological hallmark of neurodegenerative diseases. However, the role of TDP43 in neuromyelitis optica spectrum disorder (NMOSD) remains unknown. Here, our observations demonstrate an up...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhuhe Liu, Yunmeng Bai, Bingtian Xu, Haixia Wen, Kechun Chen, Jingfang Lin, Yuanyuan Wang, Jiangping Xu, Haitao Wang, Fudong Shi, Jigang Wang, Honghao Wang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neuroinflammation
Subjects:
TDP43
NMOSD
cGAS/STING
Mitochondrial dysfunction
Inflammatory activation
Online Access:https://doi.org/10.1186/s12974-025-03348-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items