TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD

TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD

Abstract Abnormality in transactivating response region DNA binding protein 43 (TDP43) is well-recognized as the pathological hallmark of neurodegenerative diseases. However, the role of TDP43 in neuromyelitis optica spectrum disorder (NMOSD) remains unknown. Here, our observations demonstrate an up...

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Main Authors: Zhuhe Liu, Yunmeng Bai, Bingtian Xu, Haixia Wen, Kechun Chen, Jingfang Lin, Yuanyuan Wang, Jiangping Xu, Haitao Wang, Fudong Shi, Jigang Wang, Honghao Wang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neuroinflammation
Subjects:
TDP43
NMOSD
cGAS/STING
Mitochondrial dysfunction
Inflammatory activation
Online Access:https://doi.org/10.1186/s12974-025-03348-z
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https://doi.org/10.1186/s12974-025-03348-z

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