Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations

Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations

Abstract TMPRSS4, a transmembrane serine protease type II, is associated with various pathological illnesses. It has been found to activate SARS-CoV-2, enhance viral infection of human small-intestinal enterocytes and is overexpressed in different types of cancers. Therefore, this study aims to diso...

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Bibliographic Details
Main Authors: Ismail Hdoufane, Mehdi Oubahmane, Youssef Habibi, Christelle Delaite, Mohammed M. Alanazi, Driss Cherqaoui
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
TMPRSS4
Homology modeling
Molecular dynamics simulations
Cancer
COVID-19
Online Access:https://doi.org/10.1038/s41598-025-86961-5
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https://doi.org/10.1038/s41598-025-86961-5

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