Uncarboxylated osteocalcin induced miR-143-3p targets SP7 and activates PI3K/Akt signaling in TNBC cells to promote invasion and migration

Uncarboxylated osteocalcin induced miR-143-3p targets SP7 and activates PI3K/Akt signaling in TNBC cells to promote invasion and migration

Triple-negative breast cancer (TNBC) is an exceptionally aggressive malignancy with poor prognosis. Patients often have elevated mortality and recurrence rates, along with a pronounced risk of distant metastasis. Our earlier research highlighted the role of uncarboxylated osteocalcin (GluOC) in fuel...

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Bibliographic Details
Main Authors: Qian Du, Jiaojiao Xu, Miao Zhang, Jianhong Yang
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Translational Oncology
Subjects:
Uncarboxylated osteocalcin
TNBC
miR-143-3p
PI3K/Akt
Invasion
Migration
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325000361
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