Interferon-gamma rescues dendritic cell calcineurin-dependent responses to Aspergillus fumigatus via Stat3 to Stat1 switching

Interferon-gamma rescues dendritic cell calcineurin-dependent responses to Aspergillus fumigatus via Stat3 to Stat1 switching

Summary: Invasive pulmonary aspergillosis is a lethal opportunistic fungal infection in transplant recipients receiving calcineurin inhibitors. We previously identified a role for the calcineurin pathway in innate immune responses to A. fumigatus and have used exogenous interferon-gamma successfully...

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Bibliographic Details
Main Authors: Amit Adlakha, Thomas J. Williams, Xinxin Shou, Anna K. Reed, Boris Lenhard, Darius Armstrong-James
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Pathophysiology
Microbiology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027627
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