Rosemarinic Acid-Induced Destabilization of Aβ Peptides: Insights from Molecular Dynamics Simulations

Rosemarinic Acid-Induced Destabilization of Aβ Peptides: Insights from Molecular Dynamics Simulations

Alzheimer’s disease (AD) is a neurodegenerative disorder marked by the progressive accumulation of amyloid-β (Aβ) plaques and tau protein tangles in the brain. These pathological aggregates interfere with neuronal function, leading to the disruption of cognitive processes, particularly memory. The d...

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Bibliographic Details
Main Authors: Liang Zhao, Weiye Jiang, Zehui Zhu, Fei Pan, Xin Xing, Feng Zhou, Lei Zhao
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Foods
Subjects:
Alzheimer’s disease
rosmarinic acid
amyloid-β peptide
molecular dynamics
free energy landscape
Poisson–Boltzmann surface area mechanics
Online Access:https://www.mdpi.com/2304-8158/13/24/4170
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