JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction.

JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction.

Less is known about the roles of c-Jun N-terminal kinase (JNK) in cholangiocarcinoma (CCA). Here, we report that JNK exerts its oncogenic action in human CCA cells, partially due to the mammalian target of rapamycin (mTOR) pathway regulated glucose-regulated protein 78 (GRP78) induction. In human CC...

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Main Authors: Chunhong Feng, Kai He, Chunyan Zhang, Song Su, Bo Li, Yuxiao Li, Chun-Yan Duan, Shaokun Chen, Run Chen, Youping Liu, Hong Li, Mei Wei, Xianming Xia, Rongyang Dai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090388&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090388&type=printable

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