The Role of TAMs in Tumor Microenvironment and New Research Progress
Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. In this...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/5775696 |
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| _version_ | 1832550416289628160 |
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| author | Yawei Feng Zhiqiang Ye Furong Song Yufeng He Jun Liu |
| author_facet | Yawei Feng Zhiqiang Ye Furong Song Yufeng He Jun Liu |
| author_sort | Yawei Feng |
| collection | DOAJ |
| description | Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. In this paper, the latest progress in the role of TAMs in the formation of tumor microenvironment is summarized. It is particularly noteworthy that cell and animal experiments show that TAMs can provide a favorable microenvironment for the occurrence and development of tumors. At the same time, clinical pathological experiments show that the accumulation of TAMs in tumor is related to poor clinical efficacy. Finally, this paper discusses the feasibility of TAMs-targeted therapy as a new indirect cancer therapy. This paper provides a theoretical basis for finding a potentially effective macrophage-targeted tumor therapy. |
| format | Article |
| id | doaj-art-580c7476a9814b75a08fac5e1f1280c9 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-580c7476a9814b75a08fac5e1f1280c92025-02-03T06:06:46ZengWileyStem Cells International1687-96782022-01-01202210.1155/2022/5775696The Role of TAMs in Tumor Microenvironment and New Research ProgressYawei Feng0Zhiqiang Ye1Furong Song2Yufeng He3Jun Liu4Department of AnesthesiologyDepartment of EmergencyDepartment of AnesthesiologyDepartment of Intensive Care MedicineDepartment of AnesthesiologyTumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. In this paper, the latest progress in the role of TAMs in the formation of tumor microenvironment is summarized. It is particularly noteworthy that cell and animal experiments show that TAMs can provide a favorable microenvironment for the occurrence and development of tumors. At the same time, clinical pathological experiments show that the accumulation of TAMs in tumor is related to poor clinical efficacy. Finally, this paper discusses the feasibility of TAMs-targeted therapy as a new indirect cancer therapy. This paper provides a theoretical basis for finding a potentially effective macrophage-targeted tumor therapy.http://dx.doi.org/10.1155/2022/5775696 |
| spellingShingle | Yawei Feng Zhiqiang Ye Furong Song Yufeng He Jun Liu The Role of TAMs in Tumor Microenvironment and New Research Progress Stem Cells International |
| title | The Role of TAMs in Tumor Microenvironment and New Research Progress |
| title_full | The Role of TAMs in Tumor Microenvironment and New Research Progress |
| title_fullStr | The Role of TAMs in Tumor Microenvironment and New Research Progress |
| title_full_unstemmed | The Role of TAMs in Tumor Microenvironment and New Research Progress |
| title_short | The Role of TAMs in Tumor Microenvironment and New Research Progress |
| title_sort | role of tams in tumor microenvironment and new research progress |
| url | http://dx.doi.org/10.1155/2022/5775696 |
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