Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity

IntroductionK-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies...

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Main Authors: Michael J. Clowers, Zahraa Rahal, Sung-Nam Cho, Avantika Krishna, Bo Yuan, Leticia G. Hamana Zorrilla, T. Kris Eckols, Moses M. Kasembeli, Samuel Liu, Stephen Peng, Marco Ramos-Castaneda, Annamarie L. Thompson, Carlos Ignacio Rodriguez Reyna, Katherine E. Larsen, Maria T. Grimaldo, Shanshan Deng, Nastaran Karimi, Cody Chou, Walter V. Velasco, Melody Zarghooni, Sayan Alekseev, Luisa M. Solis Soto, Edwin J. Ostrin, Humam Kadara, Suhendan Ekmekcioglu, David J. Tweardy, Seyed Javad Moghaddam
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
LUAD
K-ras
stat3
DC
Th1
tumor-promoting inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575181/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575181/full

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