Circulating tumor DNA in ALK-positive anaplastic large cell lymphoma: a proof-of-concept study

Circulating tumor DNA in ALK-positive anaplastic large cell lymphoma: a proof-of-concept study

Abstract In this multicenter study, we were able to detect circulating tumor DNA (ctDNA) in 87.5% of patients with the rare disease ALK + ALCL. Moreover, by analyzing ctDNA from samples collected at disease progression, we were able to identify resistance mutations to ALK inhibitors. Furthermore, ct...

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Main Authors: Damien Vasseur, Samuel Abbou, Ludovic Lacroix, Laurence Lamant, Noémie Pata-Merci, David Sibon, Francesco Facchinetti, Marc Deloger, Floriane Braye, Véronique Minard-Colin, Laurence Brugières, Etienne Rouleau, Luc Friboulet, Charlotte Rigaud
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00944-3
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https://doi.org/10.1038/s41698-025-00944-3

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