Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation
Abstract The canonical functions of vimentin in cell mechanics and migration have been recently expanded by the discovery of new roles for extracellular vimentin (ECV) in immune responses to infection, injury and cancer. In contrast with the predominantly filamentous form of intracellular vimentin,...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Cell Communication and Signaling |
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| Online Access: | https://doi.org/10.1186/s12964-025-02194-z |
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| author | Zhiyao Yuan Paul A. Janmey Christopher A. McCulloch |
| author_facet | Zhiyao Yuan Paul A. Janmey Christopher A. McCulloch |
| author_sort | Zhiyao Yuan |
| collection | DOAJ |
| description | Abstract The canonical functions of vimentin in cell mechanics and migration have been recently expanded by the discovery of new roles for extracellular vimentin (ECV) in immune responses to infection, injury and cancer. In contrast with the predominantly filamentous form of intracellular vimentin, ECV exists largely as soluble oligomers. The release of ECV from intact cells is dependent on mechanisms that regulate the assembly and disassembly of intracellular vimentin, which are influenced by discrete post-translational modifications. In this review we highlight the processes that promote the conversion of intracellular and insoluble vimentin filaments to ECV and secretion mechanisms. Insights into the regulation of ECV release from stromal and immune cells could provide new diagnostic and therapeutic approaches for assessing and controlling inflammatory diseases. |
| format | Article |
| id | doaj-art-57df2419d4004e5c8b176129cd489abb |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-57df2419d4004e5c8b176129cd489abb2025-08-20T03:27:10ZengBMCCell Communication and Signaling1478-811X2025-04-0123111410.1186/s12964-025-02194-zStructure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammationZhiyao Yuan0Paul A. Janmey1Christopher A. McCulloch2Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing UniversityDept. of Physiology, University of PennsylvaniaFaculty of Dentistry, University of TorontoAbstract The canonical functions of vimentin in cell mechanics and migration have been recently expanded by the discovery of new roles for extracellular vimentin (ECV) in immune responses to infection, injury and cancer. In contrast with the predominantly filamentous form of intracellular vimentin, ECV exists largely as soluble oligomers. The release of ECV from intact cells is dependent on mechanisms that regulate the assembly and disassembly of intracellular vimentin, which are influenced by discrete post-translational modifications. In this review we highlight the processes that promote the conversion of intracellular and insoluble vimentin filaments to ECV and secretion mechanisms. Insights into the regulation of ECV release from stromal and immune cells could provide new diagnostic and therapeutic approaches for assessing and controlling inflammatory diseases.https://doi.org/10.1186/s12964-025-02194-zVimentinExtracellular vimentin (ECV)InflammationPost-translational modifications (PTMs)Unconventional protein secretion (UPS) |
| spellingShingle | Zhiyao Yuan Paul A. Janmey Christopher A. McCulloch Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation Cell Communication and Signaling Vimentin Extracellular vimentin (ECV) Inflammation Post-translational modifications (PTMs) Unconventional protein secretion (UPS) |
| title | Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation |
| title_full | Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation |
| title_fullStr | Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation |
| title_full_unstemmed | Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation |
| title_short | Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation |
| title_sort | structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation |
| topic | Vimentin Extracellular vimentin (ECV) Inflammation Post-translational modifications (PTMs) Unconventional protein secretion (UPS) |
| url | https://doi.org/10.1186/s12964-025-02194-z |
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