Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes

Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes

ABSTRACT Background Activation of mitochondrial fission and quality control occur early in the onset of insulin resistance in human skeletal muscle. We hypothesized that differences in mitochondrial dynamics, structure and bioenergetics in humans would explain the onset and progression of type 2 dia...

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Main Authors: Wagner S. Dantas, Elizabeth C. Heintz, Elizabeth R. M. Zunica, Jacob T. Mey, Melissa L. Erickson, Kathryn P. Belmont, Analisa L. Taylor, Gangarao Davuluri, Hisashi Fujioka, Ciarán E. Fealy, Charles L. Hoppel, Christopher L. Axelrod, John P. Kirwan
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
bioenergetics
fission
fusion
mitochondria
obesity
quality control
Online Access:https://doi.org/10.1002/jcsm.13763
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https://doi.org/10.1002/jcsm.13763

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