The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis

The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis

ObjectiveDespite recent advances, the pathophysiological mechanisms underlying anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) remain incompletely understood, and comparative proteomic analyses of AAV subtypes are lacking. This study aimed to identify key molecular signalin...

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Main Authors: Erik Hellbacher, Vincent van Hoef, Alina Johansson, Ann Knight, Iva Gunnarsson, Annette Bruchfeld, Per Eriksson, Sophie Ohlsson, Solbritt Rantapää-Dahlqvist, Johanna Dahlqvist
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
ANCA
vasculitis
proteinase 3
myeloperoxidase
proteome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1600754/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1600754/full

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