Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer’s disease dementia

Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer’s disease dementia

Abstract Background A proteome-wide association study (PWAS) that integrates proteomic data with genome-wide association study (GWAS) summary data is a powerful tool for studying Alzheimer’s disease (AD) dementia. Existing PWAS analyses of AD often rely on the availability of individual-level proteo...

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Bibliographic Details
Main Authors: Tingyang Hu, Qiang Liu, Qile Dai, Aron S. Buchman, David A. Bennett, Shinya Tasaki, Yanling Wang, Nicholas T. Seyfried, Philip L. De Jager, Michael P. Epstein, Jingjing Yang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
PWAS
pQTL
TWAS
GWAS
Alzheimer’s disease
AD dementia
Online Access:https://doi.org/10.1186/s13195-025-01774-y
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https://doi.org/10.1186/s13195-025-01774-y

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