Zwitterionic poly-carboxybetaine-dexamethasone conjugates do not alleviate cartilage degeneration and synovitis in the collagenase-induced osteoarthritis model in rats

Zwitterionic poly-carboxybetaine-dexamethasone conjugates do not alleviate cartilage degeneration and synovitis in the collagenase-induced osteoarthritis model in rats

Abstract Osteoarthritis is a degenerative joint disease for which there is yet to be a disease-modifying drug available in clinics. New drug candidates often fail due to a combination of poor pharmacokinetics as well as an inability to address the complex, multifactorial nature of osteoarthritis. To...

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Main Authors: Patrick Weber, Maryam Asadikorayem, Shipin Zhang, David Fercher, Kajetana Bevc, Sami Kauppinen, Tuomas Frondelius, Tianqi Zhang, Marina Fonti, Gonçalo Barreto, Mikko A.J. Finnilä, Marcy Zenobi-Wong
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Zwitterionic polymers
Dexamethasone
CIOA
Computed tomography
Synovitis
Online Access:https://doi.org/10.1038/s41598-025-93247-3
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https://doi.org/10.1038/s41598-025-93247-3

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