Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation

Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation

Abstract Salt-inducible kinase 1 (SIK1) participates in various physiological processes, yet its involvement in regulating skeletal muscle glucose uptake remains unclear. Previously, we showed that phanginin A, a natural compound isolated from Caesalpinia sappan Linn, activated SIK1 to suppress gluc...

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Bibliographic Details
Main Authors: Yu Shi, Xing-de Wu, Yanli Liu, Yu Shen, Hui Qu, Qin-Shi Zhao, Ying Leng, Suling Huang
Format: Article
Language:English
Published: SpringerOpen 2025-04-01
Series:Natural Products and Bioprospecting
Subjects:
SIK1
Phanginin A
Class IIa HDACs
Skeletal muscle
GLUT4
Glucose uptake
Online Access:https://doi.org/10.1007/s13659-025-00504-z
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https://doi.org/10.1007/s13659-025-00504-z

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