Association between anti-Helicobacter pylori immunoglobulin G status and coronary artery disease among hypertensives: Myth or fact?
Background: Chronic persistent inflammation associated with Helicobacter pylori (H. pylori) infection accelerates vascular complications which are prone to cause atherogenesis and coronary artery disease (CAD). This study was undertaken to assess the significance of the association between H. pylori...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Journal of Current Research in Scientific Medicine |
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| Online Access: | https://journals.lww.com/10.4103/jcrsm.jcrsm_96_23 |
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| author | Gowri Subbiah Anushiya Periyannan Poongodi Lakshmi Santhanakumarasamy Surendar Subramanian Sumathi Ramalingam |
| author_facet | Gowri Subbiah Anushiya Periyannan Poongodi Lakshmi Santhanakumarasamy Surendar Subramanian Sumathi Ramalingam |
| author_sort | Gowri Subbiah |
| collection | DOAJ |
| description | Background:
Chronic persistent inflammation associated with Helicobacter pylori (H. pylori) infection accelerates vascular complications which are prone to cause atherogenesis and coronary artery disease (CAD). This study was undertaken to assess the significance of the association between H. pylori immunoglobulin G (IgG) serostatus and the occurrence of CAD among hypertensives.
Materials and Methods:
A total of 90 hypertensive subjects without stroke and CAD symptoms were tested for serum H. pylori IgG. Their electrocardiogram and echocardiogram (ECHO) outcomes were analyzed after 3 months.
Results:
Among the 90 subjects, 52 (57.8%) were H. pylori IgG positive. The adjusted odds ratio for abnormal ECHO outcome and H. pylori IgG positivity was 2.494. There was a positive correlation between H. pylori IgG positivity, sedentary lifestyle, alcoholism, and elevated serum C-reactive protein and abnormal ECHO findings suggestive of CAD.
Conclusions:
This study found a positive correlation between H. pylori IgG seropositivity and abnormal ECHO outcomes. The prevention of CAD with antimicrobial therapy for H. pylori is simple and innovative. Lifestyle modification and hand hygiene can obviate the adverse circumstances of CAD to some extent. |
| format | Article |
| id | doaj-art-57950c155bbf44e7a89d497282a2b260 |
| institution | Kabale University |
| issn | 2542-6273 2455-3069 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Current Research in Scientific Medicine |
| spelling | doaj-art-57950c155bbf44e7a89d497282a2b2602025-01-23T05:26:11ZengWolters Kluwer Medknow PublicationsJournal of Current Research in Scientific Medicine2542-62732455-30692024-01-01101849010.4103/jcrsm.jcrsm_96_23Association between anti-Helicobacter pylori immunoglobulin G status and coronary artery disease among hypertensives: Myth or fact?Gowri SubbiahAnushiya PeriyannanPoongodi Lakshmi SanthanakumarasamySurendar SubramanianSumathi RamalingamBackground: Chronic persistent inflammation associated with Helicobacter pylori (H. pylori) infection accelerates vascular complications which are prone to cause atherogenesis and coronary artery disease (CAD). This study was undertaken to assess the significance of the association between H. pylori immunoglobulin G (IgG) serostatus and the occurrence of CAD among hypertensives. Materials and Methods: A total of 90 hypertensive subjects without stroke and CAD symptoms were tested for serum H. pylori IgG. Their electrocardiogram and echocardiogram (ECHO) outcomes were analyzed after 3 months. Results: Among the 90 subjects, 52 (57.8%) were H. pylori IgG positive. The adjusted odds ratio for abnormal ECHO outcome and H. pylori IgG positivity was 2.494. There was a positive correlation between H. pylori IgG positivity, sedentary lifestyle, alcoholism, and elevated serum C-reactive protein and abnormal ECHO findings suggestive of CAD. Conclusions: This study found a positive correlation between H. pylori IgG seropositivity and abnormal ECHO outcomes. The prevention of CAD with antimicrobial therapy for H. pylori is simple and innovative. Lifestyle modification and hand hygiene can obviate the adverse circumstances of CAD to some extent.https://journals.lww.com/10.4103/jcrsm.jcrsm_96_23coronary artery diseasehelicobacter pylori immunoglobulin ghypertension |
| spellingShingle | Gowri Subbiah Anushiya Periyannan Poongodi Lakshmi Santhanakumarasamy Surendar Subramanian Sumathi Ramalingam Association between anti-Helicobacter pylori immunoglobulin G status and coronary artery disease among hypertensives: Myth or fact? Journal of Current Research in Scientific Medicine coronary artery disease helicobacter pylori immunoglobulin g hypertension |
| title | Association between anti-Helicobacter pylori immunoglobulin G status and coronary artery disease among hypertensives: Myth or fact? |
| title_full | Association between anti-Helicobacter pylori immunoglobulin G status and coronary artery disease among hypertensives: Myth or fact? |
| title_fullStr | Association between anti-Helicobacter pylori immunoglobulin G status and coronary artery disease among hypertensives: Myth or fact? |
| title_full_unstemmed | Association between anti-Helicobacter pylori immunoglobulin G status and coronary artery disease among hypertensives: Myth or fact? |
| title_short | Association between anti-Helicobacter pylori immunoglobulin G status and coronary artery disease among hypertensives: Myth or fact? |
| title_sort | association between anti helicobacter pylori immunoglobulin g status and coronary artery disease among hypertensives myth or fact |
| topic | coronary artery disease helicobacter pylori immunoglobulin g hypertension |
| url | https://journals.lww.com/10.4103/jcrsm.jcrsm_96_23 |
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