Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectives

Abstract Pyroptosis is a distinct form of programmed cell death characterized by the rupture of the cell membrane and robust inflammatory responses. Increasing evidence suggests that pyroptosis significantly affects the tumor microenvironment and antitumor immunity by releasing damage-associated mol...

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Bibliographic Details
Main Authors: Chen Huang, Jiayi Li, Ruiyan Wu, Yangqian Li, Chenliang Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Cancer
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Online Access:https://doi.org/10.1186/s12943-025-02344-4
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