Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma

Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma

Abstract Resistance to BRAF/MEK inhibitor therapy in BRAFV600‐mutated advanced melanoma remains a major obstacle that limits patient benefit. Microenvironment components including the extracellular matrix (ECM) can support tumor cell adaptation and tolerance to targeted therapy; however, the underly...

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Bibliographic Details
Main Authors: Ilona Berestjuk, Margaux Lecacheur, Alexandrine Carminati, Serena Diazzi, Christopher Rovera, Virginie Prod’homme, Mickael Ohanna, Ana Popovic, Aude Mallavialle, Frédéric Larbret, Sabrina Pisano, Stéphane Audebert, Thierry Passeron, Cédric Gaggioli, Christophe A Girard, Marcel Deckert, Sophie Tartare‐Deckert
Format: Article
Language:English
Published: Springer Nature 2021-12-01
Series:EMBO Molecular Medicine
Subjects:
DDR
extracellular matrix
melanoma
NF‐κB2
therapeutic resistance
Online Access:https://doi.org/10.15252/emmm.201911814
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https://doi.org/10.15252/emmm.201911814

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