The impact of lipidome on intervertebral disk degeneration, low back pain, and sciatica: a Mendelian randomization study

Abstract Degeneration of intervertebral discs is a significant factor in chronic lower back pain, impacting millions annually. Existing studies propose a potential link between lipids and disc disease, though causal relationships remain unclear. The objective of this study is to explore the causal c...

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Bibliographic Details
Main Authors: Ze-Yu Pang, Yi-Bo Zhu, Jun-Xian Hu, Xiao-Xiao Li, Yong-Jian Gao, Yi-Yang Wang, Qiang Zhou, Pei Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-99914-9
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