Nonlinear Dynamics of TNFR1 and TNFR2 Expression on Immune Cells: Genetic and Age-Related Aspects of Inflamm-Aging Mechanisms

Nonlinear Dynamics of TNFR1 and TNFR2 Expression on Immune Cells: Genetic and Age-Related Aspects of Inflamm-Aging Mechanisms

<b><b>Introduction:</b></b> Immunosenescence alters TNF receptor expression (TNFR1 and TNFR2), contributing to chronic inflammation (inflamm-aging) and age-related diseases. Polymorphisms in TNFRSF1A and TNFRSF1B may influence receptor expression; however, their role in age-d...

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Main Authors: Alina Alshevskaya, Julia Zhukova, Julia Lopatnikova, Filipp Vasilyev, Ivan Khutornoy, Elena Golikova, Fedor Kireev, Sergey Sennikov
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomedicines
Subjects:
TNFR1
TNFR2
age-related receptor expression
immune cell subsets
TNF signaling
genetic polymorphisms
Online Access:https://www.mdpi.com/2227-9059/13/4/852
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