Distinct gut microbiome characteristics and dynamics in patients with Parkinson’s disease based on the presence of premotor rapid-eye movement sleep behavior disorders

Distinct gut microbiome characteristics and dynamics in patients with Parkinson’s disease based on the presence of premotor rapid-eye movement sleep behavior disorders

Abstract Background Alpha-synuclein aggregation, a hallmark of Parkinson’s disease (PD), is hypothesized to often begin in the enteric or peripheral nervous system in “body-first” PD and progresses through the vagus nerve to the brain, therefore REM sleep behavior disorder (RBD) precedes the PD diag...

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Bibliographic Details
Main Authors: Jae-Yun Lee, Sungyang Jo, Jihyun Lee, Moongwan Choi, Kijeong Kim, Sangjin Lee, Hyun Sik Kim, Jin-Woo Bae, Sun Ju Chung
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Microbiome
Subjects:
Parkinson’s disease
Microbiome
Rapid eye movement sleep behavior disorders
Biofilm
Carbohydrate-active enzymes
Online Access:https://doi.org/10.1186/s40168-025-02095-w
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https://doi.org/10.1186/s40168-025-02095-w

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