Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction
Objective. Our study’s goal was to find out acute myocardial infarction (AMI) patients’ NUMB gene expression patterns and to evaluate its role as a diagnostic marker for AMI detection. Methods. Peripheral blood was drawn from 124 individuals who had an AMI and 115 patients who had stable coronary ar...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/7981637 |
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| author | Heyu Meng Lihong Li Jianjun Ruan Yanqiu Chen Zhaohan Yan Jinsha Liu Xiangdong Li Cuiying Mao Ping Yang |
| author_facet | Heyu Meng Lihong Li Jianjun Ruan Yanqiu Chen Zhaohan Yan Jinsha Liu Xiangdong Li Cuiying Mao Ping Yang |
| author_sort | Heyu Meng |
| collection | DOAJ |
| description | Objective. Our study’s goal was to find out acute myocardial infarction (AMI) patients’ NUMB gene expression patterns and to evaluate its role as a diagnostic marker for AMI detection. Methods. Peripheral blood was drawn from 124 individuals who had an AMI and 115 patients who had stable coronary artery disease (SCAD). The real-time quantitative polymerase chain reaction was used to measure the mRNA expression level of the NUMB gene in peripheral blood. Results. The AMI group’s NUMB gene expression was 0.906 (0.181–0.954), whereas the SCAD group’s expression was 1.024 (0.207–1.127). However, the AMI group had 0.885 times lower NUMB mRNA expression than the SCAD group P<0.05. Conclusion. Multivariate logistic regression evaluation found that lower NUMB expression was correlated with an increased risk of coronary artery disease. However, age and fasting plasma glucose levels were not associated with decreased NUMB expression. |
| format | Article |
| id | doaj-art-574829db33124145992d0b246293e2d5 |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-574829db33124145992d0b246293e2d52025-02-03T01:22:58ZengWileyCardiology Research and Practice2090-05972022-01-01202210.1155/2022/7981637Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial InfarctionHeyu Meng0Lihong Li1Jianjun Ruan2Yanqiu Chen3Zhaohan Yan4Jinsha Liu5Xiangdong Li6Cuiying Mao7Ping Yang8Jilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic DiagnosisJilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic DiagnosisJilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic DiagnosisJilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular DiseaseJilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular DiseaseDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyObjective. Our study’s goal was to find out acute myocardial infarction (AMI) patients’ NUMB gene expression patterns and to evaluate its role as a diagnostic marker for AMI detection. Methods. Peripheral blood was drawn from 124 individuals who had an AMI and 115 patients who had stable coronary artery disease (SCAD). The real-time quantitative polymerase chain reaction was used to measure the mRNA expression level of the NUMB gene in peripheral blood. Results. The AMI group’s NUMB gene expression was 0.906 (0.181–0.954), whereas the SCAD group’s expression was 1.024 (0.207–1.127). However, the AMI group had 0.885 times lower NUMB mRNA expression than the SCAD group P<0.05. Conclusion. Multivariate logistic regression evaluation found that lower NUMB expression was correlated with an increased risk of coronary artery disease. However, age and fasting plasma glucose levels were not associated with decreased NUMB expression.http://dx.doi.org/10.1155/2022/7981637 |
| spellingShingle | Heyu Meng Lihong Li Jianjun Ruan Yanqiu Chen Zhaohan Yan Jinsha Liu Xiangdong Li Cuiying Mao Ping Yang Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction Cardiology Research and Practice |
| title | Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction |
| title_full | Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction |
| title_fullStr | Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction |
| title_full_unstemmed | Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction |
| title_short | Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction |
| title_sort | association of low expression of numb in peripheral blood with acute myocardial infarction |
| url | http://dx.doi.org/10.1155/2022/7981637 |
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