Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway

Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway

Abstract This study aimed to evaluate the therapeutic properties of the traditional Chinese medicine Xuesanqi (XSQ, from the rhizome of Polygonum amplexicaule D. Don) in treating ulcerative colitis. We hypothesized that its many active components can alleviate symptoms of colitis by regulating the g...

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Bibliographic Details
Main Authors: Qiyuan Su, Qian Hu, Songtao Wu, Suqin Yang, Hanwen Su, Zhengjun Zhang, Chengxiu Ling
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:Natural Products and Bioprospecting
Subjects:
Colitis
Xuesanqi
Gut microbiota
Short chain fatty acids (SCFas)
MAPK/ERK/JNK signaling pathway
Tight junction (T.J.) protein
Online Access:https://doi.org/10.1007/s13659-024-00482-8
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