Integration of T cell repertoire, CyTOF, genotyping and symptomatology data reveals subphenotypic variability in COVID-19 patients

Integration of T cell repertoire, CyTOF, genotyping and symptomatology data reveals subphenotypic variability in COVID-19 patients

COVID-19 manifests a broad spectrum of clinical outcomes, from asymptomatic cases to severe disease. While several biomarkers have been proposed, comprehensive immunological analyses integrating mass cytometry (CyTOF) and T-cell receptor sequencing (TCRseq) data remain limited. In this study, we app...

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Main Authors: Fernando Marín-Benesiu, Lucia Chica-Redecillas, Sergio Cuenca-López, Carmen Entrala-Bernal, Sara Martín-Esteban, Maria Jesús Alvarez-Cubero, Luis Javier Martínez-González
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Cellular immunology
bioinformatics
COVID-19
T-cell repertoire
Latent Class Model
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037025001783
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http://www.sciencedirect.com/science/article/pii/S2001037025001783

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