ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition

ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition

Abstract Apolipoprotein E (ApoE) variants are central to Alzheimer’s disease (AD), Lewy body dementia (LBD) and Niemann-Pick disease type C (NPC). The ApoE4 variant elevates AD risk by 3-15-fold. ApoE’s normal function in lipid transport is known. The question remains how different ApoE isoforms cau...

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Bibliographic Details
Main Authors: Erika Di Biase, Kyle J. Connolly, Ingrid Crumpton, Oliver Cooper, Penelope J. Hallett, Ole Isacson
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
ApoE
Alzheimer’s risk variant
NPC1
Lipid transport
Human cellular platform
Amyloid
Online Access:https://doi.org/10.1038/s41598-025-96531-4
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https://doi.org/10.1038/s41598-025-96531-4

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