Cobalt Chloride-simulated Hypoxia Promoted Ossification of the Posterior Longitudinal Ligament Through the HIF1A–BMP4 Axis

Cobalt Chloride-simulated Hypoxia Promoted Ossification of the Posterior Longitudinal Ligament Through the HIF1A–BMP4 Axis

Background: The ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disorder predominantly observed in Asian populations. Unfortunately, there is a limited availability of conservative therapies to impede the progression of OPLL. This study investiga...

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Bibliographic Details
Main Authors: Shihao Lu, Junbin Liu, Junzhe Sheng, Aochen Xu, Zichuan Wu, Chen Xu, Jiabin Yuan, Yang Liu
Format: Article
Language:English
Published: IMR Press 2025-06-01
Series:Frontiers in Bioscience-Landmark
Subjects:
ossification of the posterior longitudinal ligament
hypoxia
hif1a
in vitro
Online Access:https://www.imrpress.com/journal/FBL/30/6/10.31083/FBL37494
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