Positional distribution and conservation of major phosphorylated sites in the human kinome

Positional distribution and conservation of major phosphorylated sites in the human kinome

The human protein kinome is a group of over 500 therapeutically relevant kinases. Exemplified by over 10,000 phosphorylated sites reported in global phosphoproteomes, kinases are also highly regulated by phosphorylation. Currently, 1008 phosphorylated sites in 273 kinases are associated with their r...

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Main Authors: Athira Perunelly Gopalakrishnan, Prathik Basthikoppa Shivamurthy, Mukhtar Ahmed, Samseera Ummar, Poornima Ramesh, Sonet Daniel Thomas, Althaf Mahin, Mahammad Nisar, Sowmya Soman, Yashwanth Subbannayya, Rajesh Raju
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
predominant phosphorylated sites
kinome classification
kinase domain
kinase family
functional phosphorylated sites
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1557835/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2025.1557835/full

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