PARP inhibitors accumulate B7-H3 on fibroblasts via blocking autophagic flux to potentiate immune evasion in ovarian cancer

PARP inhibitors accumulate B7-H3 on fibroblasts via blocking autophagic flux to potentiate immune evasion in ovarian cancer

Besides targeting tumor cells via canonical synthetic lethality, poly(ADP-ribose) polymerase inhibitors (PARPis) can remodel tumor immune microenvironment (TIME), which then affects PARPis’ anti-tumor capabilities. However, exact function of PARPis on TIME remains insufficiently explored. Here, by l...

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Bibliographic Details
Main Authors: Tian Fang, Yu Xia, Ying Li, Sen Xu, Huayi Li, Siyuan Wang, Pu Huang, Yiyu Qian, Ping Jin, Ning Jin, Cheng Xu, Zhen Wang, Xiaoming Xiong, Mengjie Wang, Dongchen Zhou, Ya Wang, Xiaoting Li, Tao Xu, Qi Zhang, Dan Liu, Yong Fang, Guang-Nian Zhao, Qinglei Gao
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Autophagy
B7-H3
cancer-associated fibroblast
ovarian cancer
PARP inhibitor
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2516294
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https://www.tandfonline.com/doi/10.1080/2162402X.2025.2516294

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