Distinct chromosomal mutation associated with cefiderocol resistance in Acinetobacter baumannii: a combined bioinformatics and mass spectrometry approach to unveil and validate the in vivo-acquired chemoresistance

Distinct chromosomal mutation associated with cefiderocol resistance in Acinetobacter baumannii: a combined bioinformatics and mass spectrometry approach to unveil and validate the in vivo-acquired chemoresistance

Acinetobacter baumannii is a significant public health concern due to the emergence of antibiotic-resistant strains. Cefiderocol (FDC), a novel siderophore cephalosporin, has shown promise as a last-line treatment for multidrug-resistant Gram-negative bacteria. However, the emergence of in vivo-acqu...

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Main Authors: Lavinia Morosi, Davide Golzato, Linda Bussini, Hygerda Guma, Federica Tordato, Federica Armanini, Zian Asif, Francesco Carella, Paola Morelli, Michele Bartoletti, Giorgio Da Rin, Erminia Casari, Giuseppe Martano, Maria Rescigno, Nicola Segata, Sara Carloni, Valeria Cento
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Microbiology
Subjects:
Acinetobacter
cefiderocol
CRAB
variant calling analysis
LC–MS/MS
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1480322/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1480322/full

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