Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential

Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential

Abstract In this study, we investigated a novel anti-cancer drug design approach by revisiting diclofenac-based carborane-substituted prodrugs. The redesigned compounds combine the robust carborane scaffold with the oxindole framework, resulting in four carborane-derivatized oxindoles and a unique z...

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Bibliographic Details
Main Authors: Christoph Selg, Vuk Gordić, Tamara Krajnović, Antonio Buzharevski, Markus Laube, Aleksandr Kazimir, Peter Lönnecke, Mara Wolniewicz, Menyhárt B. Sárosi, Jonas Schädlich, Jens Pietzsch, Sanja Mijatović, Danijela Maksimović-Ivanić, Evamarie Hey-Hawkins
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Cyclooxygenase inhibitors
Carboranes
Non-steroidal anti-inflammatory drug
Cancer
Drug repurposing
Online Access:https://doi.org/10.1038/s41598-024-81414-x
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https://doi.org/10.1038/s41598-024-81414-x

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