ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

Nearly 30% of pancreatic ductal adenocarcinomas (PDACs) exhibit a marked overexpression of monocarboxylate transporter 1 (MCT1) offering a unique opportunity for therapy. However, biochemical inhibitors of MCT1 have proven unsuccessful in clinical trials. In this study, we present an alternative app...

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Bibliographic Details
Main Authors: Jordina Rincon-Torroella, Marco Dal Molin, Brian Mog, Gyuri Han, Evangeline Watson, Nicolas Wyhs, Shun Ishiyama, Taha Ahmedna, Il Minn, Nilofer Azad, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W Kinzler, Shibin Zhou, Bert Vogelstein, Kathleen Gabrielson, Surojit Sur
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
cancer biology
pancreatic cancer
targeted therapy
MCT1
solute channel
Online Access:https://elifesciences.org/articles/94488
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https://elifesciences.org/articles/94488

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