Gut commensals-derived succinate impels colonic inflammation in ulcerative colitis

Gut commensals-derived succinate impels colonic inflammation in ulcerative colitis

Abstract Gut microbiota-derived metabolites play a crucial role in modulating the inflammatory response in inflammatory bowel disease (IBD). In this study, we identify gut microbiota-derived succinate as a driver of inflammation in ulcerative colitis (UC) by activating succinate-responsive, colitoge...

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Main Authors: Rajdeep Dalal, Srikanth Sadhu, Aashima Batra, Sandeep Goswami, Jyotsna Dandotiya, Vinayakadas K. V, Rahul Yadav, Virendra Singh, Kartikey Chaturvedi, Rahul Kannan, Shakti Kumar, Yashwant Kumar, Deepak Kumar Rathore, Deepak B. Salunke, Vineet Ahuja, Amit Awasthi
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-025-00672-3
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https://doi.org/10.1038/s41522-025-00672-3

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