Enantiomeric profile of promethazine in metabolic studies in liver microsomes

Promethazine (PMZ) is metabolized in the liver giving rise to chiral metabolites, including promethazine sulfoxide (PMZSO) and desmonomethyl promethazine (DMPMZ). Other metabolites, such as dioxopromethazine (DOPMZ), hydroxy promethazine (PMZOH), N-desmethyl-promethazine sulfoxide, and promethazine...

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Bibliographic Details
Main Authors: Maria Miguel Coelho, Bárbara Silva, Carla Fernandes, Fernando Remião, Maria Elizabeth Tiritan
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Chromatography Open
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Online Access:http://www.sciencedirect.com/science/article/pii/S277239172400032X
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