Chronic intermittent hypoxia impairs BM-MSC osteogenesis and long bone growth through regulating histone lactylation

Chronic intermittent hypoxia impairs BM-MSC osteogenesis and long bone growth through regulating histone lactylation

Abstract Background Chronic intermittent hypoxia (CIH) caused by OSA often results in serious complications. However, the adverse effects of CIH on bone growth and development are often overlooked. Methods CIH intervention was conducted using an OxyCycler model A84 system for 8 h per day (from 8:00...

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Bibliographic Details
Main Authors: Fang Chen, Meizhen Gu, Hongming Xu, Shasha Zhou, Zilu Shen, Xiaoyan Li, Liangchao Dong, Pin Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Chronic intermittent hypoxia
Bone development
BM-MSCs
Histone lactylation
PPARγ
Online Access:https://doi.org/10.1186/s12967-025-06849-w
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https://doi.org/10.1186/s12967-025-06849-w

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