Clinical relevance of protein-truncating variants of germline DNA repair genes in prostate cancer

Clinical relevance of protein-truncating variants of germline DNA repair genes in prostate cancer

Abstract Background Interpreting genetic variants remains a challenge in prostate cancer (PCa). Although many annotation tools are available for prioritizing causal variants, the clinical relevance of these variants is rarely studied. Methods We collected a cohort study that included 274 PCa patient...

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Bibliographic Details
Main Authors: Yu-Hsuan Joni Shao, Cai-Sian Liao, Yu-Ching Hsu, Yu-Chiao Chiu, Tsai-Jung Lu, Yen-Chuan Ou, Tzu-Hung Hsiao
Format: Article
Language:English
Published: BMC 2024-10-01
Series:BMC Cancer
Subjects:
Protein-truncating variant
Germline mutation
DNA repair gene
Prostate cancer
Online Access:https://doi.org/10.1186/s12885-024-13045-4
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https://doi.org/10.1186/s12885-024-13045-4

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