MAPK Signaling‐Mediated RFNG Phosphorylation and Nuclear Translocation Restrain Oxaliplatin‐Induced Apoptosis and Ferroptosis

MAPK Signaling‐Mediated RFNG Phosphorylation and Nuclear Translocation Restrain Oxaliplatin‐Induced Apoptosis and Ferroptosis

Abstract Chemotherapy resistance remains a major challenge in the treatment of colorectal cancer (CRC). Therefore, it is crucial to develop novel strategies to sensitize cancer cells to chemotherapy. Here, the fringe family is screened to determine their contribution to chemotherapy resistance in CR...

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Main Authors: Yuqin Di, Xiang Zhang, Xiangqiong Wen, Jiale Qin, Lvlan Ye, Youpeng Wang, Mei Song, Ziyang Wang, Weiling He
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
apoptosis and ferroptosis
MAPK signaling
nuclear RFNG
oxaliplatin chemosensitivity
p53 activity
Online Access:https://doi.org/10.1002/advs.202402795
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https://doi.org/10.1002/advs.202402795

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