The TRPA1 cation channel is upregulated by cigarette smoke in mouse and human macrophages modulating lung inflammation

The TRPA1 cation channel is upregulated by cigarette smoke in mouse and human macrophages modulating lung inflammation

Abstract Cigarette smoke (CS) is a well-known source of several inflammatory, cytotoxic and genotoxic compounds that cause chronic lung diseases. The transient receptor potential ankyrin 1 (TRPA1), a smoking-responsive, non-selective cation channel, is expressed by both capsaicin-sensitive peptiderg...

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Main Authors: Anita Steib, Katalin Rozmer, Éva Szőke, József Kun, Nelli Farkas, Diána Feller, Judit Pongrácz, Krisztina Pohóczky, Zsuzsanna Helyes
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
TRPA1
Alveolar macrophage
Cigarette smoke exposure
TGFβ
Airway inflammation
3D human lung spheroid
Online Access:https://doi.org/10.1038/s41598-025-95662-y
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https://doi.org/10.1038/s41598-025-95662-y

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