Genetically distinct within-host subpopulations of hepatitis C virus persist after Direct-Acting Antiviral treatment failure.

Analysis of viral genetic data has previously revealed distinct within-host population structures in both untreated and interferon-treated chronic hepatitis C virus (HCV) infections. While multiple subpopulations persisted during the infection, each subpopulation was observed only intermittently. Ho...

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Bibliographic Details
Main Authors: Lele Zhao, Matthew Hall, Prahalad Giridhar, Mahan Ghafari, Steven Kemp, Haiting Chai, Paul Klenerman, Eleanor Barnes, M Azim Ansari, Katrina Lythgoe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012959
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