The pharmacokinetics and Concentration-QTc analysis of a new etomidate analog ET-26-HCl: a phase I trial in healthy Chinese subjects

The pharmacokinetics and Concentration-QTc analysis of a new etomidate analog ET-26-HCl: a phase I trial in healthy Chinese subjects

Methoxetamine hydrochloride (ET-26-HCl) is a novel short-acting intravenous general anesthetic that retains the advantages of etomidate while minimizing its impact on adrenal cortical function. A single-center, randomized, open-label, placebo-controlled clinical trial was conducted using concentrati...

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Bibliographic Details
Main Authors: Kun He, Wenyu Zhang, Xiangran Kong, Lize Li, Lei Diao, Qing Wen, Guohai Su, Xiaoran Yang, Hongyan Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
C-QTc modeling
pharmacokinetics
methoxyetomidate hydrochloride
QTc effect
etomidate acid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1534717/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1534717/full

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