Adenosine A<sub>2B</sub> Receptor Antagonism Interferes with TGF-β Cellular Signaling Through SMAD2/-3 and p65-Nf-κB in Podocytes and Protects from Phenotypical Transformation in Experimental Diabetic Glomerulopathy

Adenosine A<sub>2B</sub> Receptor Antagonism Interferes with TGF-β Cellular Signaling Through SMAD2/-3 and p65-Nf-κB in Podocytes and Protects from Phenotypical Transformation in Experimental Diabetic Glomerulopathy

Studies have emphasized alleviating fibrogenesis through interference with adenosine signaling in experimental diabetic nephropathy. We found that the in vivo antagonism of the adenosine A<sub>2B</sub> receptor (A<sub>2B</sub>AR) using MRS1754 in diabetic rats impedes the dia...

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Main Authors: Ignacio Arias, Claudia Jara, Pablo Mendoza-Soto, Yessica Nahuelpán, Claudio Cappelli, Carlos Oyarzún, Diego Carrillo-Beltrán, Claudia Quezada-Monrás, Angelo Torres-Arévalo, Rody San Martín
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
diabetic nephropathy
TGF-beta 1
adenosine receptors
glomerulosclerosis
Online Access:https://www.mdpi.com/2073-4409/14/12/890
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