Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus
Repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex has been used to treat patients with subjective tinnitus. While rTMS is known to induce morphological changes in healthy subjects, no study has investigated yet whether rTMS treatment induces grey matter (GM) changes in tinni...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/132058 |
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| author | Astrid Lehner Berthold Langguth Timm B. Poeppl Rainer Rupprecht Göran Hajak Michael Landgrebe Martin Schecklmann |
| author_facet | Astrid Lehner Berthold Langguth Timm B. Poeppl Rainer Rupprecht Göran Hajak Michael Landgrebe Martin Schecklmann |
| author_sort | Astrid Lehner |
| collection | DOAJ |
| description | Repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex has been used to treat patients with subjective tinnitus. While rTMS is known to induce morphological changes in healthy subjects, no study has investigated yet whether rTMS treatment induces grey matter (GM) changes in tinnitus patients as well, whether these changes are correlated with treatment success, and whether GM at baseline is a useful predictor for treatment outcome. Therefore, we examined magnetic resonance images of 77 tinnitus patients who were treated with rTMS of the left temporal cortex (10 days, 2000 stimuli/day, 1 Hz). At baseline and after the last treatment session high-resolution structural images of the brain were acquired and tinnitus severity was assessed. For a subgroup of 41 patients, additional brain scans were done after a follow-up period of 90 days. GM changes were analysed by means of voxel based morphometry. Transient GM decreases were detectable in several brain regions, especially in the insula and the inferior frontal cortex. These changes were not related to treatment outcome though. Baseline images correlated with change in tinnitus severity in the frontal cortex and the lingual gyrus, suggesting that GM at baseline might hold potential as a possible predictor for treatment outcome. |
| format | Article |
| id | doaj-art-56109a82ee034ca3be9adddb3bea9049 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-56109a82ee034ca3be9adddb3bea90492025-02-03T07:23:51ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/132058132058Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective TinnitusAstrid Lehner0Berthold Langguth1Timm B. Poeppl2Rainer Rupprecht3Göran Hajak4Michael Landgrebe5Martin Schecklmann6Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93053 Regensburg, GermanyDepartment of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93053 Regensburg, GermanyDepartment of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93053 Regensburg, GermanyDepartment of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93053 Regensburg, GermanyDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Social Foundation Bamberg, Buger Straße 80, 96049 Bamberg, GermanyDepartment of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93053 Regensburg, GermanyDepartment of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93053 Regensburg, GermanyRepetitive transcranial magnetic stimulation (rTMS) of the temporal cortex has been used to treat patients with subjective tinnitus. While rTMS is known to induce morphological changes in healthy subjects, no study has investigated yet whether rTMS treatment induces grey matter (GM) changes in tinnitus patients as well, whether these changes are correlated with treatment success, and whether GM at baseline is a useful predictor for treatment outcome. Therefore, we examined magnetic resonance images of 77 tinnitus patients who were treated with rTMS of the left temporal cortex (10 days, 2000 stimuli/day, 1 Hz). At baseline and after the last treatment session high-resolution structural images of the brain were acquired and tinnitus severity was assessed. For a subgroup of 41 patients, additional brain scans were done after a follow-up period of 90 days. GM changes were analysed by means of voxel based morphometry. Transient GM decreases were detectable in several brain regions, especially in the insula and the inferior frontal cortex. These changes were not related to treatment outcome though. Baseline images correlated with change in tinnitus severity in the frontal cortex and the lingual gyrus, suggesting that GM at baseline might hold potential as a possible predictor for treatment outcome.http://dx.doi.org/10.1155/2014/132058 |
| spellingShingle | Astrid Lehner Berthold Langguth Timm B. Poeppl Rainer Rupprecht Göran Hajak Michael Landgrebe Martin Schecklmann Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus Neural Plasticity |
| title | Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus |
| title_full | Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus |
| title_fullStr | Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus |
| title_full_unstemmed | Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus |
| title_short | Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus |
| title_sort | structural brain changes following left temporal low frequency rtms in patients with subjective tinnitus |
| url | http://dx.doi.org/10.1155/2014/132058 |
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